The present invention relates to ethynyl derivatives of formula (I) wherein R1 is phenyl, which is optionally substituted by 1-2 halogen atoms; selected from fluorine or chlorine; or to a pharmaceutically acceptable acid addition salt in enantiomerically pure form. It has been found that the compounds of general formula (I) are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
申请公布号
WO2014012851(A1)
申请公布日期
2014.01.23
申请号
WO2013EP64747
申请日期
2013.07.12
申请人
F. HOFFMANN-LA ROCHE AG;HOFFMANN-LA ROCHE INC.
发明人
JAESCHKE, GEORG;LINDEMANN, LOTHAR;STADLER, HEINZ;VIEIRA, ERIC