摘要 |
PROBLEM TO BE SOLVED: To provide a solid pharmaceutical product for photodynamic treatment of such as cervical cancer.SOLUTION: The solid pharmaceutical product contains a photosensitizer which is 5-aminolevulinic acid ester (5-ALA ester) represented by formula (I) or a pharmaceutically acceptable salt thereof, and at least one of pharmaceutically acceptable carrier or excipient. The pharmaceutically acceptable carrier or excipient is hard fat or a mixture of the hard fat and an additive. The solid pharmaceutical product is in the form of a suppository. The solid pharmaceutical product is preferably adapted for insertion into the uterus, vagina or cervix. The melting point thereof is preferably 30 to 37°C. The melting point of the mixture of the hard fat and the additive is preferably 31 to 33°C. Formula (I) is RN-CHCOCH-CHCO-OR, where Rrepresents a substituted or unsubstituted, straight-chained, branched or cyclic alkyl group, and each Rindependently represents a hydrogen atom. |