发明名称 |
SOLID FORMS OF (R)-2-(5-(2-(3-ETHYLUREIDO)-6-FLUORO-7-(TETRAHYDROFURAN-2-YL)-1H-BENZO[D]IMIDAZOL-5-YL)PYRIMIDIN-2-YL)PROPAN-2-YL DIHYDROGEN PHOSPHATE AND SALTS THEREOF |
摘要 |
The invention relates to solid forms of the Formula (I) wherein X is -PO(OH)2, -PO(OH)O-M+, or -PO(O-)2s2M+,wherein M is a monovalent cation such as Na+, K+, Li+, or NH4 +. The invention also provides pharmaceutically acceptable compositions comprising the solid form of he compound and method of using the compositions in the treatment of various disorders. |
申请公布号 |
WO2014015105(A1) |
申请公布日期 |
2014.01.23 |
申请号 |
WO2013US51008 |
申请日期 |
2013.07.18 |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
O'DOWD, HARDWIN;MACIKENAS, DAINIUS;SONG, BIN |
分类号 |
C07D405/14;A61K31/506;A61P31/04;C07F9/6558 |
主分类号 |
C07D405/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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