RNAI PHARMACEUTICAL COMPOSITION CAPABLE OF SUPPRESSING EXPRESSION OF KRAS GENE

摘要

Provided are: a composition which can suppress the expression of KRAS gene and comprises a double-stranded nucleic acid that serves as a medicinal agent and lipid particles, wherein an antisense strand in the double-stranded nucleic acid comprises a nucleotide sequence complementary to a sequence that is represented by any one of SEQ ID NOs: 1 to 3 and is composed of at least 19 contiguous nucleotides contained in mRNA for KRAS gene, and each of the lipid particles comprises a cationic lipid represented by formula (I) (wherein R1 and R2 may be the same as or different from each and independently represent a linear or branched alkyl, alkenyl or alkynyl group having 12 to 24 carbon atoms, L1 and L2 may be the same as or different from each other and independently represent -CO-O- or -O-CO-, a and b may be the same as or different from each and independently represent 1 to 3, and R3 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkenyl group having 3 to 6 carbon atoms); and others.