发明名称 |
MEMBRANE-TARGETING AMINOGLYCOSIDE-BASED CATIONIC AMPHIPHILES AND THERAPEUTIC USES |
摘要 |
<p>The present invention relates to amphiphilic aminoglycoside (AG) derivatives, especially derivatives of tobramycin, kanamycin A and paromomycin comprising hydrophobic side chains linked to the AG moiety by various linkers. These novel derivatives are useful as broad spectrum antibacterial agents targeting bacterial cell membranes, while having minimal toxicity due to non-selective targeting of eukaryotic cell membranes. The present invention further relates to methods for preparing the novel derivatives, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, especially as membrane-targeting antibacterial agents for treating bacterial infections, and for inhibiting bio film growth.</p> |
申请公布号 |
WO2014013495(A1) |
申请公布日期 |
2014.01.23 |
申请号 |
WO2013IL50612 |
申请日期 |
2013.07.18 |
申请人 |
RAMOT AT TEL-AVIV UNIVERSITY LTD. |
发明人 |
FRIDMAN, MICHA;HERZOG, IDO M.;FELDMAN, MARK;BERKOV-ZRIHEN, YIFAT |
分类号 |
C07H15/22;C07H11/00;C07H13/06 |
主分类号 |
C07H15/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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