发明名称 |
SMALL MOLECULE ANTAGONISTS OF BACTERIAL QUORUM-SENSING RECEPTORS |
摘要 |
A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote Caenorhabditis elegans from quorum-sensing-mediated killing by the bacterial pathogen Chromobacterium violaceum. The saving of C. elegans demonstrates the use of these molecules as small molecule antimicrobials. |
申请公布号 |
US2014024707(A1) |
申请公布日期 |
2014.01.23 |
申请号 |
US201213550961 |
申请日期 |
2012.07.17 |
申请人 |
BASSLER BONNIE L.;SWEM LEE R.;ULRICH SCOTT M.;O'LOUGHLIN COLLEEN T. |
发明人 |
BASSLER BONNIE L.;SWEM LEE R.;ULRICH SCOTT M.;O'LOUGHLIN COLLEEN T. |
分类号 |
A01N43/08;A61K31/365 |
主分类号 |
A01N43/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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