The present invention provides an antibody comprising an antigen binding domain which binds to human IL-12 and human IL-23. The antibody binds human IL-12p40 existing as a monomer (human IL-12p40) and as a homodimer (human IL-12p80) and the antibody inhibits the binding of human IL-12 to human IL-12R beta2 and human IL-23 to human IL-23R but does not inhibit the binding of human IL-12 or human IL-23 or human IL-12p40 or human IL-12p80 to human IL-12Rbeta1.
申请公布号
EP2326668(A4)
申请公布日期
2014.01.22
申请号
EP20090806241
申请日期
2009.08.14
申请人
TEVA PHARMACEUTICALS AUSTRALIA PTY LTD
发明人
CLARKE, ADAM, WILLIAM;DOYLE, ANTHONY GERARD;JENNINGS, PHILIP, ANTHONY;POULTON, LYNN, DOROTHY;WAI, BERNADETTE;POW, ANDREW, JAMES;KOPSIDAS, GEORGE