发明名称 |
MICROFLUIDIC SYSTEM HAVING MONOLITHIC NANOPLASMONIC STRUCTURES |
摘要 |
A microfluidic system has a monolithic biocompatible substrate with both a surface having an ordered array of nano-scale elements for plasmonic response monitoring and a network of microchannels. Advantageously, low-volume consumption, rapid low-cost fabrication of molds with easily interchangeable microfluidic channel layouts, mass production, and in situ label-free real-time detection of cellular response, viability, behavior and biomolecular binding using plasmonic techniques can be provided. A ratio of greater than 0.2 of the cross-sectional dimension and the spacing between the nano-scale elements is useful for plasmonic response monitoring. Producing such a system involves a master mold with the nano-scale elements etched into a hard substrate, and the network provided in a soft membrane bonded to the hard substrate. A stamp may be created by setting a settable liquid polymer or metal placed in the master mold. Features of the intended device can be transferred to a polymeric substrate using the stamp. |
申请公布号 |
EP2686154(A1) |
申请公布日期 |
2014.01.22 |
申请号 |
EP20120757703 |
申请日期 |
2012.03.12 |
申请人 |
NATIONAL RESEARCH COUNCIL OF CANADA |
发明人 |
MALIC, LIDIJA;MORTON, KEITH;VERES, TEODOR |
分类号 |
B01L3/00;B82Y30/00;G01N21/55;G01N21/65 |
主分类号 |
B01L3/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|