发明名称 |
Combination of chemotherapy and administration of glioma-antigen-pulsed dendritic cells in the treatment of glioma |
摘要 |
The invention relates to the treatment of cancer, and particularly to the treatment of cancers of the central nervous system, such as glioblastoma multiforme. A dual therapeutic approach is provided, including the administration of a dendritic cell-based cancer vaccine and a regimen of chemotherapy. The two therapies may be administered concurrently with one another and/or with an initial vaccination preceding chemotherapy. In various embodiments, the dendritic cell-based cancer vaccine includes either primed or unprimed dendritic cells; for instance, the dendritic cells may be autologous tumor antigen-presented dendritic cells. The dual therapeutic approach of the instant invention beneficially influences the chemosensitivity of a mammal with cancer. |
申请公布号 |
EP1676132(B1) |
申请公布日期 |
2014.01.22 |
申请号 |
EP20040795865 |
申请日期 |
2004.10.20 |
申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
WHEELER, CHRISTOPHER;DAS, ASHA;BLACK, KEITH |
分类号 |
A61K45/06;A61K31/203;A61K31/282;A61K31/454;A61K31/704;A61K33/24;A61K39/00;C12N5/02;C12N5/08 |
主分类号 |
A61K45/06 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|