发明名称 |
ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS |
摘要 |
Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form. |
申请公布号 |
EP2480253(B1) |
申请公布日期 |
2014.01.22 |
申请号 |
EP20110767839 |
申请日期 |
2011.09.01 |
申请人 |
NOVARTIS AG;IRM LLC |
发明人 |
SINGH, MANMOHAN;SKIBINSKI, DAVID, A.G.;WU, TOM, YAO-HSIANG;LI, YONGKAI;CORTEZ, ALEX;ZHANG, XIAOYUE;ZOU, YEFEN;HOFFMAN, TIMOTHY, Z.;PAN, JIANFENG;YUE, KATHY |
分类号 |
A61K39/00;A61K39/095;C07D239/48;C07D471/04;C07D487/04 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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地址 |
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