发明名称 |
USE OF 5-HYDROXY-2-HYDROXYMETHYL- Y -PYRONE (HMP) AS A LEISHMANICIDAL AGENT |
摘要 |
The present invention refers to the use of HMP (a secondary metabolite obtained from Aspergillus fungi) as an agent that intensifies the mechanism of macrophage activation, leading to the death of L. (Leishmania) amazonensis, the etiologic agent of cutaneous leishmaniasis. The main mechanism of action of this agent is the activation of the microbicidal activity of host cells, through increased superoxide production, number of lysosomes, actin and microtubule filament polymerization and increased spreading, typical of activated cells. Additionally, HMP represents a molecule of easy acquisition, presents an efficient combat mechanism with no adverse reactions and capacity to inhibit the development of promastigotes and amastigotes forms. Finally, results suggest HMP to be a potential candidate for use against cutaneous leishmaniasis at a minimal concentration of 50 μg/mL. |
申请公布号 |
EP2337560(B1) |
申请公布日期 |
2014.01.22 |
申请号 |
EP20090806250 |
申请日期 |
2009.08.14 |
申请人 |
UNIVERSIDADE FEDERAL DO PARA |
发明人 |
SANTOS, ALBERDAN SILVA;SILVA, EDILENE OLIVEIRA DA;NASCIMENTO, JOSE LUIZ MARTINS DO;ALVES, CLAUDIO NAUM;RODRIGUES, ANA PAULA DRUMOND;CARVALHO, ANTONIO SERGIO DA COSTA |
分类号 |
A61K31/351;A61P33/02 |
主分类号 |
A61K31/351 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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