USE OF INTRACELLULAR ENZYMES FOR THE RELEASE OF COVALENTLY LINKED BIOACTIVES
摘要
The present invention relates to targeting an intracellular enzyme for release of covalently linked bioactives which results in a synergistic effect between the bioactives. The present invention relates to the use of bioactives that are directly connected covalently or through a covalent molecular linker which have increased therapeutic activity when released as the free bioactives by intracellular enzymes as compared to when the bioactives are administered individually (i.e. not covalendy linked). Further, methods are described of administering to patients in need thereof, bioactives as linked bioactives having increased therapeutic activity. Accordingly, this invention also relates to methods of treating patients for certain diseases.
申请公布号
EP2685969(A2)
申请公布日期
2014.01.22
申请号
EP20120761015
申请日期
2012.03.16
申请人
CATABASIS PHARMACEUTICALS, INC.
发明人
JIROUSEK, MICHAEL R.;MILNE, JILL C.;CARNEY, DAVID;BEMIS, JEAN E.;VU, CHI B.