发明名称 |
CURCUMIN COMBINATION WITH ANTI-TYPE 2 DIABETIC DRUGS FOR PREVENTION AND TREATMENT OF DISEASE SEQUELAE, DRUG-RELATED ADVERSE REACTIONS, AND IMPROVED GLYCEMIC CONTROL |
摘要 |
<p>Compositions and methods for treating type 2 diabetes and its sequelae by intravenous or subcutaneous administration of formulations of synthesized curcumin (diferuloylmethane) and concomitantly one or more anti-diabetic agents to human subjects are disclosed herein. The composition of the present invention may be used to: (i) treat patients with diabetes in advanced stages with evidence of any or all encephalopathy, retinopathy, nephropathy, pancreatitis or neoplasias; (ii) treat patients with diabetic disease status without symptomatic or pathologic evidence of associated sequelae but requiring better glycemic control than that offered by standard of care anti-diabetic; and (iii) patients with objective signs or symptoms of sequelae from diabetes of anti-diabetic drugs. One three-drug combination of the present invention includes a slow release PLGA-curcumin and an oral gliptin (DPP-4)-inhibitor or any incretin-mimetic and metformin.</p> |
申请公布号 |
EP2685963(A2) |
申请公布日期 |
2014.01.22 |
申请号 |
EP20120757689 |
申请日期 |
2012.03.15 |
申请人 |
SIGNPATH PHARMA INC. |
发明人 |
HELSON, LAWRENCE |
分类号 |
A61K9/127;A61K31/155;A61K38/28;A61K47/30;A61K47/48;A61P3/00;A61P3/10 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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