发明名称 |
KINESIN INHIBITORS AS CANCER THERAPEUTICS |
摘要 |
<p>The invention provides novel compounds having a substituted imidazole ring, and methods of using such compounds for the treatment of certain disorders such as hematological cancers and solid tumors. The compounds of the invention are tri-substituted imidazole derivatives that inhibit KSP. These compounds are also useful for the treatment of drug resistant tumors, such as solid tumors that express elevated levels of P-glycoprotein.</p> |
申请公布号 |
EP2229170(B1) |
申请公布日期 |
2014.01.22 |
申请号 |
EP20080863009 |
申请日期 |
2008.12.12 |
申请人 |
NOVARTIS AG |
发明人 |
ABRAMS, TINYA;BARSANTI, PAUL;DUHL, DAVID;FAURE, MICHEL;RENHOWE, PAUL A.;WALTER, ANNETTE OLGA |
分类号 |
A61K31/4164;A61P35/00;C07D233/00 |
主分类号 |
A61K31/4164 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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