METHOD FOR PRODUCING AROMATIC UNSATURATED COMPOUND

摘要

The present invention provides a process for producing an aromatic unsaturated compound of the formula (4)
wherein Ar represents an optionally substituted aromatic group or an optionally substituted heteroaromatic group, and Y represents an electron withdrawing group,
which comprises reacting (a) a compound of the formula (1)
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒAr-€•H€ƒ€ƒ€ƒ€ƒ€ƒ(1)
wherein Ar has the same meaning as defined above with (b) a compound of the formula (2)
wherein Y has the same meaning as defined above, and Z represents a lower alkoxy, or
a compound of the formula (3)
wherein Y and Z have the same meanings as defined above, in the presence of (c) an acid or a compound which generates a mineral acid by its hydrolysis.
formula (1) is a compound of the formula (5)
wherein R 1 represents a phenyl optionally substituted by halogen(s), a hydrogen or an alkyl and R 2 represents an alkyl or a phenyl optionally substituted by halogen(s), and
the compound of the formula (4) is a compound of the formula (6)
wherein R 1 and R 2 have the same meanings as defined above. A process for producing fluvastatin which comprises carrying out a process according to claim 1 to obtain a compound of formula (4) which is a compound of formula (7)
and then converting the compound of formula (7) to fluvastatin.