发明名称 |
AMINO-DIHYDROOXAZINE AND AMINO-DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA-SECRETASE MODULATORS AND THEIR MEDICAL USE |
摘要 |
<p>The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R2, R7, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.</p> |
申请公布号 |
EP2547686(B1) |
申请公布日期 |
2014.01.22 |
申请号 |
EP20110714873 |
申请日期 |
2011.03.14 |
申请人 |
AMGEN INC. |
发明人 |
CHEN, JIAN, J.;ZHONG, WENGE;YANG, BRYANT;QIAN, WENYUAN;LOPEZ, PATRICIA;WHITE, RYAN;WEISS, MATTHEW;JUDD, TED;POWERS, TIMOTHY;CHENG, YUAN;DINEEN, THOMAS;EPSTEIN, OLEG;LOW, JONATHAN;MARX, ISAAC;MINATTI, ANA ELENA;PARAS, NICK, A.;POTASHMAN, MICHELE |
分类号 |
C07D498/10;A61K31/537;A61K31/5386;A61K31/547;A61P25/28;C07D498/20;C07D513/10;C07D513/20 |
主分类号 |
C07D498/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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