| 摘要 |
2-Nitroimidazoles having filaricidal activity of the formula <IMAGE> I wherein A is one of the groups <IMAGE> -C(R3)=C(R1)(R2),-CHBr-CH2Br or -CH2-CCl=CH2; n is 1, 2, 3 or 4; R1 and R2 are hydrogen or C1-3-alkyl and R3 is hydrogen, C1-3-alkyl, chlorine or bromine, and processes for their preparation are described. The compounds of formula I and compounds of formula <IMAGE> VII wherein R4 is -CH2-CH2OH, -CH2-CHOH-CH2OCH3, -CH2-CHOH-CH2OH or <IMAGE> are useful in the treatment of filariasis is also described.
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