发明名称 |
BIOMARKERS FOR PREDICTING THE RECURRENCE OF COLORECTAL CANCER METASTASIS |
摘要 |
The present invention includes biomarkers and methods for predicting recurrence-free survival and determination of risk for colorectal liver metastasis (LM) by determining a level of microsatellite instability at tetranucleotide repeats (EMAST) and at mono- and a dinucleotide repeat loci (MSI-L) or a SMARCA2R-LOH in colorectal cancer (CRC) patients. Results obtained indicate that stage II and III patients with MSI-M had a shorter recurrence-free survival than the rest of patients with high levels of MSI (MSI-H) or with highly stable microsatellites, and that MSI-M is an independent predictor for recurrent distant metastasis in primary stage II and III CRCs. It was found that SMARCA2R-LOH and MSI-M are found in stage IV primary CRC and LM tissues. |
申请公布号 |
EP2686450(A1) |
申请公布日期 |
2014.01.22 |
申请号 |
EP20120761204 |
申请日期 |
2012.03.16 |
申请人 |
BAYLOR RESEARCH INSTITUTE |
发明人 |
KOI, MINORU;BOLAND, C., RICHARD |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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