Process for producing trifluoromethylpyridines

摘要

A trifluoromethylpyridine selected from the group consisting of alpha -trifluoromethylpyridine, gamma -trifluoromethylpyridine, a bis(trifluoromethyl)pyridine and chlorides thereof which have 1 to 3 chlorine atoms in its pyridine nucleus is produced by reacting a pyridine derivative selected from the group consisting of alpha -picoline, gamma -picoline and a lutidine with chlorine and anhydrous hydrogen fluoride at a temperature of 300 DEG to 600 DEG C. in a vapor phase in the presence of a diluent and a catalyst comprising a fluoride of a metallic element selected from the group consisting of aluminum, chromium, iron, nickel, manganese, cobalt and copper.