发明名称 |
Genetic vasectomy by overexpression of PRML-EGFP fusion protein in spermatids |
摘要 |
The present invention provides a genetically-modified non-human animal whose somatic and germ cells contain an exogenous gene encoding a recombinant fusion protein, wherein the presence, and expression, of said recombinant fusion protein renders said genetically-modified non-human animal sterile. Tools for generating such sterile genetically-modified non-human animal as well as methods of use thereof are also provided. |
申请公布号 |
US8633348(B2) |
申请公布日期 |
2014.01.21 |
申请号 |
US201013392145 |
申请日期 |
2010.08.26 |
申请人 |
PELCZAR PAWEL;BUCH THORSTEN;PETERS ANTOINE;NOVARTIS FORSCHUNGSSTIFTUNG, ZWEIGNIEDERLASSUNG, FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH;UNIVERSITAET ZUERICH |
发明人 |
PELCZAR PAWEL;BUCH THORSTEN;PETERS ANTOINE |
分类号 |
A01K67/027;C12N15/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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