发明名称 |
Method for producing recombinant antibody and antibody fragment thereof |
摘要 |
A recombinant antibody or the antibody fragment thereof which specifically reacts with an extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or the antibody fragment thereof; a method for producing the recombinant antibody or the antibody fragment thereof; a method for immunologically detecting CCR4, a method for immunologically detecting a cell which expressed CCR4 on the cell surface, a method for depleting a cell which expresses CCR4 on the cell surface, and a method for inhibiting production of Th2 cytokine, which comprise using the recombinant antibody according or antibody fragment thereof; a therapeutic or diagnostic agent for Th2-mediated immune diseases; and a therapeutic or diagnostic agent for a blood cancer. |
申请公布号 |
US8632996(B2) |
申请公布日期 |
2014.01.21 |
申请号 |
US201213492465 |
申请日期 |
2012.06.08 |
申请人 |
SHITARA KENYA;HANAI NOBUO;SHOJI EMI;SAKURADA MIKIKO;FURUYA AKIKO;NAKAMURA KAZUYASU;NIWA RINPEI;SHIBATA KENJI;YAMASAKI MOTOO;KYOWA HAKKO KIRIN CO., LTD. |
发明人 |
SHITARA KENYA;HANAI NOBUO;SHOJI EMI;SAKURADA MIKIKO;FURUYA AKIKO;NAKAMURA KAZUYASU;NIWA RINPEI;SHIBATA KENJI;YAMASAKI MOTOO |
分类号 |
C12P21/00;A61P11/06;A61P17/00;A61P27/14;A61P37/08;C07K16/28;C12N15/13;C12P21/08;G01N33/543 |
主分类号 |
C12P21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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