MK2 COUPLING INHIBITOR WITH TRIAZINOINDOLE DERIVATIVE AS ACTIVE COMPONENT

摘要

PROBLEM TO BE SOLVED: To provide a pharmaceutical agent for prevention and treatment of articular rheumatism, psoriasis, osteoarthritis, asthma, atherosclerosis, Parkinson's disease, Alzheimer's disease, ischemia-reperfusion injury, and periodontitis.SOLUTION: An MK2 coupling inhibitor contains a compound represented by the following general formula (1), its salt or their solvate as an active component. In general formula (1), Rand Rrepresent a hydrogen atom, a halogen atom, a hydroxyl group, or a Calkyl group, Rand Reach independently represent a hydrogen atom, a hydroxyl group, or a Calkyl group, and R, R, R, and Reach independently represent a hydrogen atom, a hydroxyl group, a halogen atom, or a Calkyl group.