发明名称 |
Adenovirusvektorer som udtrykker enkeltkædet interleukin-12 og 4-1BB ligand |
摘要 |
The invention relates to viral vectors comprising nucleic acid sequences coding for single chain interleukin-12 (single chain IL-12 or scIL12) and a costimulator protein, and to the use of vectors for gene therapy, especially for the treatment of tumors. The invention further relates to adenoviral vectors containing nucleic acid sequences having a sequence homology of at least 90% in relation to the sequence displayed in FIGS. 19 and 20 (IL-12), in FIG. 21 (4-1BB ligand) and in FIG. 22 (IL-2) and optionally also one of the sequences displayed in FIG. 23A (B7-1) or 23B (B7-2). |
申请公布号 |
DK1556411(T3) |
申请公布日期 |
2014.01.20 |
申请号 |
DK20030757951T |
申请日期 |
2003.10.10 |
申请人 |
PROVECS MEDICAL GMBH |
发明人 |
WAEHLER, REINHARD;SCHNIEDERS, FRANK |
分类号 |
C07K14/54;A61K38/17;A61K38/20;A61K48/00;C07K14/55;C07K14/705;C12N15/861 |
主分类号 |
C07K14/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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