发明名称 |
PROCESS FOR PREPARING 1-FLUOROPHENYLBUTYL-4-(2-PYRIMIDINYL)-PIPERAZINE DERIVATIVES AND PHARMACEUTICS COMPRISING SUCH ACTIVE SUBSTANCES |
摘要 |
Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is a pyrimidin-2-yl ring and the other is a 4 carbon chain attached to a p-fluorophenyl ring at the terminal carbon. The terminal carbon of this butylene chain is also bonded to an oxygen atom as part of a carbonyl, carbinol, or ketal functionality. These compounds possess psychotropic properties, particularly atypical antipsychotic activity of good duration. By virtue of pre-clinical pharmacological testing, these compounds appear useful as potential antipsychotic agents which lack the typical movement disorder side-effects of standard antipsychotic agents. |
申请公布号 |
HU193949(B) |
申请公布日期 |
1987.12.28 |
申请号 |
HU19850000831 |
申请日期 |
1985.03.05 |
申请人 |
BRISTOL-MYERS CO,US |
发明人 |
YEVICH,JOSEPH P,US;LOBECK JUN,WALTER G,US |
分类号 |
C07D239/42;A61K;A61K31/505;A61P25/18;C07D;C07D239/00;C07D239/47;C07D317/00;C07D317/12;C07D403/04;C07D405/12 |
主分类号 |
C07D239/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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