发明名称 |
DNA REPAIR ENZYME INHIBITOR NANOPARTICLES AND USES THEREOF |
摘要 |
This invention relates generally to the discovery of novel nanoparticles for delivery of DNA double-stranded break (DSB) repair enzyme inhibitors such as wortmannin or wortmannin analogues. In one embodiment, these nanoparticles comprise a polylactide polyglycolide (PLGA) copolymer and a polyethylene glycol (PEG). In addition methods of treatment and methods of enhancing radiation treatments are also provided. |
申请公布号 |
US2014017165(A1) |
申请公布日期 |
2014.01.16 |
申请号 |
US201213979271 |
申请日期 |
2012.01.11 |
申请人 |
WANG ZHUANG;PACOLD MICHAEL EDWARD;WERNER MICHAEL EDWARD;KARVE SHRIRANG |
发明人 |
WANG ZHUANG;PACOLD MICHAEL EDWARD;WERNER MICHAEL EDWARD;KARVE SHRIRANG |
分类号 |
A61K31/366;A61K9/16;A61K47/34 |
主分类号 |
A61K31/366 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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