| 摘要 |
The present invention relates to methods of treating muscle injury, tendon damage, or a muscle degenerative disorder by administering inhibitors of prolyl 4-hydroxylase. The method comprises the administration of a prolyl 4-hydroxylase inhibitor to a patient. The inventors have shown that prolyl 4-hydroxlase inhibitors reduce muscle damage and preserve muscle function when administered prior to muscle damage in an in vivo assay for muscle function. Furthermore, the inventors have shown that when a prolyl 4-hydroxylase inhibitor is administered after muscle damage in the same assay, recovery of muscle function is enhanced. |
