发明名称 |
Bio-orthogonal drug activation |
摘要 |
The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives. |
申请公布号 |
AU2012257418(A1) |
申请公布日期 |
2014.01.16 |
申请号 |
AU20120257418 |
申请日期 |
2012.05.16 |
申请人 |
KONINKLIJKE PHILIPS N.V. |
发明人 |
ROBILLARD, MARC STEFAN;TEN HOEVE, WOLTER;VERSTEEGEN, RONNY MATHIEU;ROSSIN, RAFFAELLA;HOEBEN, FREEK JOHANNES MARIA |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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