发明名称 |
QUINAZOLINONE-BASED ONCOGENIC-RAS-SELECTIVE LETHAL COMPOUNDS AND THEIR USE |
摘要 |
The present invention provides, inter alia, compounds having the structure (1) compositions containing such compounds are also provided. Methods for using such compounds or compositions for treating or ameliorating the effects of a cancer having a cell that harbors an oncogenic RAS mutation, for modulating a lipoxygenase in a ferroptosis cell death pathway, and for depleting reduced glutathione (GSH) in a cell harboring an oncogenic RAS mutation are further provided. |
申请公布号 |
WO2014011973(A2) |
申请公布日期 |
2014.01.16 |
申请号 |
WO2013US50244 |
申请日期 |
2013.07.12 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;STOCKWELL, BRENT R.;WELSCH, MATTHEW;YANG, WAN SEOK |
发明人 |
STOCKWELL, BRENT R.;WELSCH, MATTHEW;YANG, WAN SEOK |
分类号 |
A61K31/517;C07D403/14 |
主分类号 |
A61K31/517 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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