| 摘要 |
This invention relates to compounds of Formula (I) and (l)(a) wherein R1, R2 and R3 are each independently hydrogen, halo, C1-C4alkyl, or C1-C4alkoxy; R4 is hydrogen or methyl; provided that at least one of R1, R2 and R3 is not hydrogen; or a pharmaceutically acceptable salt thereof. As well as the use of quinazolinediones for the modulation, notably the inhibition of the activity of tankyrases (TNKS1 and TNKS2). Suitably, the present invention relates to the use of quinazolinediones in the treatment of cancer, fibrosis and other hyperproliferative diseases through this mechanism. |
