发明名称 |
MESENCHYMAL-LIKE STEM CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS, METHODS AND USES THEREOF |
摘要 |
<p>The present invention relates to methods of generating and expanding hitman embryonic stem eel! derived mesenchymal-iike stem/siromal cells. These hES-MSCs are characterized at least in part by the low level of expression of IL-6. These cells are useful for the prevention and treatment of T cell related autoimmune disease, especially multiple sclerosis, as well as for delivering agents across the blood-brain barrier and the blood-spinal cord barrier. Also provided is a method of selecting clinical grade hES-MSC and a method of modifying MSC to produced a MSC with specific biomarker profile. The modified MSC are useful for treatment of various diseases.</p> |
申请公布号 |
CA2876499(A1) |
申请公布日期 |
2014.01.16 |
申请号 |
CA20132876499 |
申请日期 |
2013.06.27 |
申请人 |
IMSTEM BIOTECHNOLOGY, INC. |
发明人 |
WANG, XIAOFANG;XU, REN-HE |
分类号 |
A61K48/00;C12N5/00;C12N5/02;C12N15/85 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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