发明名称 |
Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl} -4-(dimethylamino)-2-butenamide and crystalline forms thereof |
摘要 |
The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, (NERATINIB) methods of preparing crystalline maleate salt forms, the associated compounds, such as its degradation and impurities and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family. |
申请公布号 |
AU2008312474(B2) |
申请公布日期 |
2014.01.16 |
申请号 |
AU20080312474 |
申请日期 |
2008.10.16 |
申请人 |
WYETH LLC |
发明人 |
LU, QINGHONG;HADFIELD, ANTHONY F.;KU, MANNCHING SHERRY;CHEAL, GLORIA K.;CHEW, WARREN;MIRMEHRABI, MAHMOUD |
分类号 |
C07D401/12;A61K31/404;A61P35/00 |
主分类号 |
C07D401/12 |
代理机构 |
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