| 摘要 |
<p>A novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R 1 , R 2 , R 3 , ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.</p> |
| 申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
SUGIMOTO, YUUICHI;UOTO, KOUICHI;MIYAZAKI, MASAKI;SETOGUCHI, MASAKI;TANIGUCHI, TORU;YOSHIDA, KEISUKE;YAMAGUCHI, AKITAKE;YOSHIDA, SHOKO;WAKABAYASHI, TAKANORI |
