| 摘要 |
<p>The present invention relates to a drug delivery system comprising polydiacetylene liposome, in which a lipid bilayer is formed by a mixture of 10,12-pentacosadiynoic acid (PCDA), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and N-palmitoyl homocysteine (PHC); and a drug to be delivered is encapsulated in an isolated space inside the polydiacetylene liposome. The PDA liposome drug delivery system according to the present invention comprises a lipid layer formed by mixing different phospholipids, apart from polydiacetylene, thereby preventing the stably encapsulated drug from being released. In addition, since the PDA liposome drug delivery system is pH-sensitive, the shape and size thereof can be readily changeable through the formation of a liposome-liposome conjugate by the improved sensitivity thereof under a specific acidic condition, thereby enabling selective drug release, and thus can be applied as a drug delivery system for various target materials. Also, the release of a drug can be controlled by adjusting pH conditions of the surroundings, and a drug release process can be monitored in real time through the fluorescence expressed by stimulation of the surroundings.</p> |
