发明名称 |
METHOD FOR SCREENING FOR COMPOUND CAPABLE OF ENHANCING OR INHIBITING OATP1B1 TRANSPORT ACTIVITY, AND METHOD FOR DETERMINING EXPRESSION LEVEL OF OATP1B1 |
摘要 |
<p>The present invention provides a method of screening for a compound that enhances or inhibits the transport activity of OATP1B1, using dichlorofluorescein. The present invention also provides a use of dichlorofluorescein in measurement of the expression level of OATP1B1. The present invention further provides a method for measuring the expression level of OATP1B1 in test cells, using dichlorofluorescein. The present invention further provides a use of a kit including dichlorofluorescein and positive cells expressing OATP1B1 in measurement of the expression level of OATP1B1 in test cells.</p> |
申请公布号 |
EP2684963(A1) |
申请公布日期 |
2014.01.15 |
申请号 |
EP20120755075 |
申请日期 |
2012.03.06 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
IZUMI SAKI;KOMORI TAKAFUMI;NOZAKI YOSHITANE |
分类号 |
G01N33/58 |
主分类号 |
G01N33/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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