P-TOLUENE SULFONIC ACID SALT OF 5-AMINO-3-(2'-O-ACETYL-3'-DEOXY-ß-D-RIBOFURANOSYL)-3H-THIAZOLE[4,5-D]PYRIMIDINE-2-ONE AND METHODS FOR PREPARATION

摘要

THE PRESENT INVENTION RELATES TO P-TOLUENE SULFONIC ACID SALT OF 5-AMINO-3-(2'-O-ACETYL¬-3'-DEOXY-BETA-D-RIBOFURANOSYL)-3H-THIAZOLO [4,5-D]PYRIMIDINE-2-ONE AND TO ITS USE IN TREATING CONDITIONS SUCH AS VIRAL INFECTIONS, TUMORS, AND CANCER. ALSO DISCLOSED IS A METHOD OF PREPARING THE P-TOLUENE SULFONIC ACID SALT OF 5-AMINO -3-(2'-O-ACETYL-3'-DEOXY-¬?-D-RIBOFURANOSYL)-3H-THIAZOLO [4,5-D]PYRIMIDINE-2-ONE AND METHODS FOR PRODUCING FURANOSE COMPOUNDS WHICH ARE USEFUL INTERMEDIATES IN THE PREPARATION OF PHARMACEUTICAL COMPOUNDS SUCH AS P-TOLUENE SULFONIC ACID SALT OF 5-AMINO-3 -(2' -O-ACETYL-3?? DEOXY-?-D-RIBOFURANOSYL)-3H-THIAZOLO [4, 5-D]PYRIMIDINE-2-ONE AND THE LIKE. (FIGURE 1)