发明名称 |
Imidazole compounds that modulate HSP90 activity |
摘要 |
Compounds of formula (I), pharmaceutical compositions comprising compounds of formula (I) and methods of inhibiting Hsp90 in a cell, treating or preventing a proliferation disorder in a mammal and treating cancer in a mammal comprising administering a compound of formula (I) to a patient or a cell Variable R5 is an optionally substituted heteroaryl; an optionally substituted 6 to 14-membered aryl; a bicyclic 9-member heterocycle optionally substituted at any substitutable nitrogen or carbon atoms; or a substituent R18, defined herein. Ring A is an aryl or a heteroaryl optionally further substituted with one or more substituents in addition to R3. Substituent R3 is defined herein. |
申请公布号 |
US8629285(B2) |
申请公布日期 |
2014.01.14 |
申请号 |
US20060502347 |
申请日期 |
2006.08.10 |
申请人 |
YING WEIWEN;DU ZHENJIAN;FOLEY KEVIN;SYNTA PHARMACEUTICALS CORP. |
发明人 |
YING WEIWEN;DU ZHENJIAN;FOLEY KEVIN |
分类号 |
A61K31/52;A61K31/4178;A61K31/4188;A61K31/437;C07D401/04;C07D403/04;C07D417/04;C07D473/00 |
主分类号 |
A61K31/52 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|