发明名称 |
Detección de patrones individuales de reacción de linfocitos T contra antígenos asociados a tumor (TAA) en pacientes con tumor como base para la vacunación terapéutica individual de pacientes |
摘要 |
Identifying the preferential target antigens of antitumor T cells comprises isolating T cells from the blood of a tumor patient, transfecting autologous dendritic or B cells with a selection of mRNAs coding for tumor-associated antigens, contacting the T cells with the dendritic or B cells, and identifying the antigens recognized by the T cells. Independent claims are also included for: (1) identifying a tumor in a patient on the basis of an antigen expression pattern determined as above; (2) producing an individualized antitumor vaccine by identifying tumor-associated antigens as above and formulating the antigens as a vaccine; (3) treating a tumor disease on the basis of an antigen expression pattern determined as above. - ACTIVITY : Cytostatic. - MECHANISM OF ACTION : Vaccine. |
申请公布号 |
ES2437872(T3) |
申请公布日期 |
2014.01.14 |
申请号 |
ES20070856294T |
申请日期 |
2007.11.28 |
申请人 |
JOHANNES GUTENBERG-UNIVERSITAET MAINZ |
发明人 |
FATHO, MARTINA;WESARG, EMMANUELLE;LENNERZ, VOLKER;VAN DER BRUGGEN, PIERRE;WOELFEL, THOMAS;DEBO, SERENA |
分类号 |
C07K14/47;G01N33/50 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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