发明名称 |
Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation |
摘要 |
The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human. |
申请公布号 |
US8629318(B2) |
申请公布日期 |
2014.01.14 |
申请号 |
US20100855383 |
申请日期 |
2010.08.12 |
申请人 |
LIDDLE CHRISTOPHER;GOODWIN BRYAN JAMES;ROBERTSON GRAHAM;UNIVERSITY OF SYDNEY |
发明人 |
LIDDLE CHRISTOPHER;GOODWIN BRYAN JAMES;ROBERTSON GRAHAM |
分类号 |
A01K67/027;A61K49/00;C12N5/00;C12N9/02;C12N15/85;G01N33/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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