BICYCLIC CARBOXYLIC ACID LEUKOTRIENE B4 ANTAGONISTS

摘要

The invention relates to a compound of formulae: wherein R<2>, each occurence, independently, is hydroxy, lower alkoxy or NR<3>R<4>, wherein R<3> and R<4>, independently, are hydrogen or lower alkyl, and Ph is phenyl and, for the compound of formula C, its geometric isomer, and, when R<2> is hydroxy, a pharmaceutically acceptable salt thereof with a base, and an inert carrier. The compounds of formula A, B and C are potent leukotriene B4 antagonists and are therefore useful in the treatment of inflammatory diseases such as psoriasis, rhinitis, chronic obstructive pulmonary disease, inflammatory bowel disease, asthma, acute respiratory distress syndrome, cystic fibrosis, allergy, arthritis such as rheumatoid arthritis, dermatitis such as contact dermatitis, NSAID-induced gastropathy, gout, ischemia/ reperfusion injury, and trauma induced inflammation, such as spinal cord injury.