| 摘要 |
<p>The present invention relates to a pharmaceutical composition containing the extract of Stemona japonica root and inhibiting the onset of inflammatory bowel disease caused by cigarette smoke, a food composition containing the same extract and preventing or overcoming the inflammatory bowel disease caused by cigarette smoke, a method for suppressing the expression of inflammatory cytokines using the pharmaceutical composition, and a method for inhibiting a decrease in the number of intestinal lactobacillus using the pharmaceutical composition. Since the pharmaceutical composition in the present invention containing the extract of Stemona japonica, the pharmaceutical composition decreases the expression level of MMP12, which is known to destroy the inflammatory cytokines such as IL-1β, TNF-α, and IL-6, elastin, and collagen, concomitant to the onset of the inflammatory bowel disease, and inhibits the decrease in the number of intestinal lactobacillus, thereby can be widely used for developing safe and effective medicine against the inflammatory bowel disease. [Reference numerals] (AA) Negative control group; (BB) Positive control group; (CC) Experimental group</p> |
