MOLÉCULA PARCERIA DE ANTICORPO CONJUGADA,COMPOSIÇÃO, MÉTODO DE INIBIÇÃO DO CRESCIMENTO DE UMA CÉLULA DE TUMOR EXPRESSANDO CD19, MÉTODO DE EXAUSTÃO DE CÉLULAS B EM UM SUJEITO E MÉTODO DE TRATAMENTO DE CÂNCER EM UM SUJEITO

摘要

Human monoclonal antibodies that specifically bind to CD19 with high affinity are disclosed The antibodies are capable of internalizing into CD19-expressing cells or are capable of mediating antigen dependent cellular cytotoxicity Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided Antibody-partner molecule conjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies are also provided Also provided are methods for detecting CD19, as well as methods for treating cancers, such as B cell malignancies, for example, non-Hodgkin's lymphoma, chronic lymphocytic leukemias, follicular lymphomas, diffuse large cell lymphomas of B lineage, and multiple myelomas using an anti-CD 19 anti-body