MANUFACTURING METHOD FOR EXTRACT OF CULTURE BROTH IN VEGETABLE WORMS CONTAINING HIGH CONCENTRATED CORDYCEPIN AND THE COMPOSITION COMPRISING THE SAME FOR TREATING OR PREVENTING VASCULAR DISEASES

摘要

The present invention relates to a method for manufacturing extract of culture broth for Cordyceps containing high concentrated cordycepin and a composition containing the same extract for treating or preventing vascular diseases. The extract of the culture broth for Cordyceps manufactured by the method in the present invention has a high collect rate of the cordycepin, thereby manufacturing the extract containing a high content of the cordycepin, and an active ingredient containing the cordycepin is extracted from the culture broth for Cordyceps formerly discarded, thereby bringing cost saving effect. Also, the extract of the culture broth for Cordyceps has an excellent effect in treating the vascular diseases, thereby being used as a pharmaceutical composition for hypertension, angina, myocardial infarction, ischemic heart disease, heart failure, complications occurs after percutaneous transluminal coronary angioplasty, cerebral infarction, cerebral hemorrhage, and stroke, etc. [Reference numerals] (AA) Culture broth for Cordyceps; (BB) Decompression concentration; (CC,EE) Control to be pH 4.0 or greater; (DD) Concentrate; (FF) First stir and extract the butane after adding 100% of butane; (GG) First extract; (HH,KK) Residue; (II) Second stir and extract after adding saturated butane; (JJ) Second extract; (LL) Decompression concentration, azeotropic concentration, and freezing-drying; (MM) Extract of culture broth for Cordyceps