发明名称 |
Process and intermediate for the preparation of terazosin hydrochloride dihydrate |
摘要 |
<p>A process for the preparation of 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (terazosin hydrochloride dihydrate comprises the steps of reacting 4-amino-2-chloro-6,7-dimethoxy-quinazoline with N-(2-tetrahydrofuroyl)piperazine in an anhydrous polar organic solvent in the absence of an added acid scavenger to produce anhydrous 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride (Form IV) and thereafter converting the product of that step to 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate.</p> |
申请公布号 |
EP0708104(A1) |
申请公布日期 |
1996.04.24 |
申请号 |
EP19950103188 |
申请日期 |
1995.03.06 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
MANNINO, ANTHONY;HEITMANN, WAYNE R.;HENRY, RODGER F.;HORROM, BRUCE W. |
分类号 |
A61K31/505;A61P9/00;A61P9/12;C07D405/12;(IPC1-7):C07D405/12 |
主分类号 |
A61K31/505 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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