| 摘要 |
FIELD: biotechnologies.SUBSTANCE: poxvirus includes defective gene I4L and/or F4L and target nucleic acid containing suicide gene. Besides, a composition containing such a poxvirus, its use for obtaining medical preparation and a treatment method of proliferative disease or disease with increased activity of osteoclasts with its application are described. The proposed group of inventions can be used in medicine.EFFECT: poxvirus of variolovaccine has oncolytic activity.34 cl, 18 dwg, 5 tbl |
