发明名称 |
Procedimiento para la producción de derivado de diamina |
摘要 |
The present invention provides a method for producing a compound represented by formula (A), the method comprising the steps of: (a) mixing a compound represented by formula (B) with p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate at less than 1 molar equivalent with respect to the compound represented by formula (B) in a solvent under heating; (b) adding additional p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate to the mixed solution under cooling, wherein the additional p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate is added in such an amount that the total molar equivalent thereof with the p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate of step (a) is 1 molar equivalent or more with respect to the compound represented by formula (B) of step (a); and (c) subsequently allowing the mixed solution to crystallize to obtain the compound represented by formula (A). |
申请公布号 |
ES2437346(T3) |
申请公布日期 |
2014.01.10 |
申请号 |
ES20090833424T |
申请日期 |
2009.12.15 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
KOYAMA, TAKEO |
分类号 |
C07D513/04;A61K31/444;A61P7/02 |
主分类号 |
C07D513/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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