| 摘要 |
Use of at least one 4-aminopiperidine derivative as an agent to fight against wrinkles including wrinkles of expression and/or to relax skin and/or facial features, is claimed. Use of at least one 4-aminopiperidine derivative of formula (I) and its salts, optical isomers or solvates, as an agent to fight against wrinkles including wrinkles of expression and/or to relax skin and/or facial features, is claimed. Alk1, Alk2 : divalent group comprising saturated linear 1-10C-alkylene, unsaturated linear 2-10C-alkylene, or optionally saturated branched 3-10C-alkylene; Ar1 : phenyl (optionally substituted with one or more substituents of R1, -OR1, -N(R1)(R2) or -COX) (preferred); X : OR1, NH(R1) or N(R1)(R2); R3 : divalent group comprising saturated linear 1-10C-alkylene, unsaturated linear 2-10C-alkylene or optionally saturated branched 3-10C-alkylene (all optionally substituted by one or more substituents of -OR1 or -N(R1)(R2), or H (preferred); R1, R2 : H, saturated linear 1-7C-alkyl, unsaturated linear 2-7C alkyl, or optionally saturated branched or cyclic 3-7C alkyl; and R4 : R1, -OR1 or -N(R1)(R2), preferably H. [Image]. |
