| 发明名称 |
(Z)-2-[(3-CARBAMOYL-4,5,6,7-TETRAHYDROBENZO[b]THIEN-2-YL)AMINO]-4-(4-R-PHENYL)-4-OXOBUT-2-ENOIC ACIDS, HAVING ANALGESIC ACTIVITY |
| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to organic chemistry and specifically to biologically active substances which are (Z)-2-[(3-carbamoyl-4,5,6,7-tetrahydrobenzo [b]thien-2-yl)amino]-4-(4-R-phenyl)-4-oxobut-2-enoic acids of general formula (1-3). The acids (1-3) are obtained by reacting 4-(4-R-phenyl)-2,4-dioxobutanoic acid with an amide of 2-amino-4,5,6,7-tetrahydro[b]thiophene-3-carboxylic acid in a medium of ethyl alcohol at 60°C, followed by extraction of the end product using existing methods.EFFECT: obtaining novel compounds with high output, having marked analgesic activity and low toxicity.1 tbl, 4 ex |
| 申请公布号 |
RU2503671(C1) |
申请公布日期 |
2014.01.10 |
| 申请号 |
RU20120132788 |
申请日期 |
2012.07.31 |
| 申请人 |
FEDERAL'NOE GOSUDARSTVENNOE BJUDZHETNOE OBRAZOVATEL'NOE UCHREZHDENIE VYSSHEGO PROFESSIONAL'NOGO OBRAZOVANIJA "PERMSKIJ GOSUDARSTVENNYJ NATSIONAL'NYJ ISSLEDOVATEL'SKIJ UNIVERSITET" |
发明人 |
SHIPILOVSKIKH SERGEJ ALEKSANDROVICH;RUBTSOV ALEKSANDR EVGEN'EVICH;MAKHMUDOV RAMIZ RAGIBOVICH |
| 分类号 |
C07D333/68;A61K31/381;A61P29/00 |
主分类号 |
C07D333/68 |
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