Compounds for enzyme inhibition

摘要

COMPOUNDS FOR ENZYME INHIBITION Peptide-based compounds including heteroatom-containing, three-membered 5 rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti inflammatory properties and inhibition of cell proliferation. Oral administration of 10 these peptide-based proteasome inhibitors is possible due to their bioavailability profiles.