USE OF L-CARNOSINE FOR THE PREPARATION OF A NANOPREPARATION HAVING AN ANTIHYPOXIC AND ANTIOXIDANT ACTIVITY

摘要

The invention relates to medicine, specifically to neurology and cardiology, namely to the production of a drug in the form of a biologically active nanopreparation having antihypoxic and antioxidant activity. The use of liposomal containers comprising L-carnosine for the preparation of a nanopreparation having antihypoxic and antioxidant activity increases the stability of the L-carnosine and the life thereof in an organism whilst increasing the efficiency of the action of L-carnosine in small doses, as well as extending the range of such drugs. The mentioned use of L-carnosine for the preparation of a nanopreparation having antihypoxic and antioxidant activity comprises a combination of L-carnosine with a combination of substances selected from the group consisting of phospholipids and nonpolar lipids with the following ratio of components, in % by mass: L-carnosine - 1.1 - 1.2; nonpolar lipids such as triglycerides, cholesterol, free fatty acids, DL-alpha-tocopherol - 1.2 - 2.5; phospholipids such as phosphatidylcholine, phosphatidyl ethanolamine, lysophosphatidylcholine, lysophosphatidyl ethanolamine, sphingomyelin - 95.3 - 96.3. In this application as well, the drug prepared is used to improve tolerance to brain ischemia, to improve recovery after acute hypoxia, and to increase the antioxidant status of brain tissues. Furthermore, the drug is produced in the form of liposomes containing L-carnosine.