发明名称 |
DECOY PEPTIDES INHIBITING PROTEIN PHOSPHATASE 1-MEDIATED DEPHOSPHORYLATION OF PHOSPHOLAMBAN |
摘要 |
The present invention relates to decoy peptide or polypeptide consisting of a peptide sequence represented by the following Formula I: X1-Ala-X2-X3-Ile-Glu-X4 (I). It is noteworthy that the decoy peptide or polypeptide of the present invention significantly elevates phosphorylation levels of PLB by inhibiting PP1-mediated dephosphorylation. In addition, the decoy peptide or polypeptide provides cardio-protective effects by restoring of SERCA2a activity and inotropic effect of enhancing myocardial contractility. The present invention will contribute greatly to the prevention or treatment of diseases associated with PLB. |
申请公布号 |
WO2014007584(A1) |
申请公布日期 |
2014.01.09 |
申请号 |
WO2013KR06009 |
申请日期 |
2013.07.05 |
申请人 |
GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY |
发明人 |
PARK, WOO JIN;HAJJAR, ROGER J.;OH, JAE GYUN |
分类号 |
C07K14/00;A61K38/08;A61K38/10;A61K38/16;A61P9/00;C07K7/00 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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